nAChR
Nicotinergic acetylcholine receptors are made up of 5 subunits, symmetrically arranged around a central pore (ion channel). It is considered the best-characterized LGIC and a prototypical structure for the class of 4TM receptors. nAChRs are found mainly in postsynaptic membranes of central nervous system synapses and of the neuromuscular endplate. The physiological signal to which nAChR responds is the neurotransmitter acetylcholine, but it is also activated by nicotine. The assembly of combinations of subunits (17 distinct subunits have been identified) results in a large number of different receptors with a high variety of functional diversity as a result[1].
[1] Ligand-Gated Ion Channels. F. Hucho, C. Weise. Angew.Chem.Int.Ed. 2001, 40, 3100-3116.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2074 | Varenicline tartrate | Selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist | €90.00 | |
| 1384 | Varenicline dihydrochloride | Nicotinic acetylcholine receptor agonist | €80.00 | |
| 3151 | QND7 | nAChR antagonist (α7 sub-unit selective) | €130.00 | |
| 2908 | PNU 282987 hydrochloride | nAChR agonist (α7 sub-unit selective) | €90.00 | |
| 2109 | PHA 543613 dihydrochloride | nAChR agonist (α7 sub-unit selective) | €120.00 | |
| 3286 | Penehyclidine hydrochloride | Anticholinergic drug | €130.00 | |
| 2860 | GTS 21 dihydrochloride | Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist | €90.00 | |
| 2621 | GAT107 | allosteric agonist and PAM of α7 nAChR | €110.00 | |
| 4113 | Encenicline hydrochloride | Selective and brain-penetrant α7 nicotinic acetylcholine receptor (nAChR) partial agonist | Recently added | €120.00 |
| 2401 | AT 1001 | High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects | €95.00 | |
| 2694 | 4BP-TQS | Allosteric agonist of α7 nAChR | €110.00 | |
| 1076 | (±)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €95.00 | |
| 1078 | (-)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €155.00 | |
| 1077 | (+)-Epibatidine dihydrochloride | Nicotinic acetylcholine receptor agonist | €155.00 | |