A group of potassium channels with a predicted membrane topology of two TMDs (M1–M2) and a pore (P) domain comprises inward rectifier channels (Kir) and ATP-sensitive (KATP) channels. Currently, seven subfamilies (Kir1–7) have been identified, the majority of which form K+ channels with varying degrees of inward rectification when expressed in heterologous expression systems. They can be classified into four functional groups: classical Kir channels (Kir2.x) are constitutively active, G protein-gated Kir channels (KG or Kir3.x) are regulated by G protein-coupled receptors, ATP-sensitive K+ channels (Kir6.x) are tightly linked to cellular metabolism, and K+ transport channels (Kir1.x, Kir4.x, Kir5.x, and Kir7.x) [1].

[1] H. Hibino et al. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev. 2010 Jan;90(1):291-366.

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Axon ID Name Description From price
2064 Glibenclamide potassium salt KATP channel blocker; inhibits SUR1 €50.00
3503 Glipizide KATP channel blocker; inhibits SUR1 €50.00
1757 HMR 1098 K+ channel blocker (SUR1/Kir6.2 selective) €95.00
4046 Levosimendan Calcium sensitiser €60.00
3490 Minoxidil K+ channel opener (ATP sensitive, vascular) €50.00
2436 ML 297 First potent and selective activator of the GIRK potassium channel €95.00
3641 Nateglinide KATP channel blocker; inhibits SUR1 €60.00
1647 NN 414 K+ channel opener (SUR1/Kir6.2 selective) €110.00
3365 Repaglinide K+ channel blocker (SUR1/Kir6.2 selective) €90.00
3593 VU0468554 Selective cardiac GIRK inhibitor €110.00
3675 VU6036720 hydrochloride First potent and selective inhibitor of heteromeric Kir4.1/5.1 inward rectifier potassium channels €130.00
3799 VU6036721 hydrochloride Inactive enantiomer of VU6036720 hydrochloride €130.00

12 Item(s)

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