Enzymes

A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].


[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

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Axon ID Name Description From price
2787 ASP 9521 Inhibitor of 17 β–hydroxysteroid dehydrogenase type 5 €75.00
2166 AT 13148 dihydrochloride ATP-competitive inhibitor of multi-AGC kinases €85.00
1539 AT 7519 mesylate CDK inhibitor €80.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
2288 ATB 346 Orally active hydrogen sulfide-releasing cyclooxygenase inhibitor €110.00
2276 Atglistatin Potent and selective inhibitor of adipose triglyceride lipase (ATGL) €90.00
2043 Atorvastatin calcium Inhibitor of HMG-CoA reductase €70.00
1597 Aurora A inhibitor I Aurora A inhibitor €125.00
1630 Aurora A inhibitor II Aurora A inhibitor €125.00
2748 Autophinib PIK3C3/Vps34 inhibitor €120.00
2226 AVL 292 Potent, selective, covalent BTK inhibitor €120.00
2345 AZ 20 Potent, orally active and selective inhibitor of ATR protein kinase €105.00
1642 AZ 3146 MPS1 kinase inhibitor €90.00
1545 AZ 628 B-Raf and C-Raf protein kinase inhibitor €80.00
1778 AZ 960 JAK2 inhibitor €95.00

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