Enzymes

A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].


[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

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Axon ID Name Description From price
1754 Apixaban Factor Xa inhibitor €125.00
2006 Apoptosis Activator 2 A cell-permeable apoptosis activator €75.00
2251 Apoptozole Inhibitor of ATPase activity of Hsc70 and Hsp70 €95.00
2883 APPA Aldose reductase inhibitor €105.00
1957 Apremilast PDE4 inhibitor €105.00
2611 APS-2-79 Inhibitor of KSR and oncogenic Ras signaling €90.00
2394 AR-42 HDAC inhibitor €125.00
2167 AR-A 014418 ATP-competitive GSK-3 inhibitor €85.00
2136 AR03 Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €105.00
2307 ARM1 hydrobromide Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4 €92.00
2941 ARN 272 Selective inhibitor of FAAH-like anandamide transporter (FLAT)  Recently added €90.00
2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor €95.00
1424 AS 252424 PI3K inhibitor (p110-γ specific) €85.00
1436 AS 252424 bispotassium salt PI3K inhibitor (p110-γ specific) €95.00
2002 AS 602801 JNK inhibitor, which inhibited JNK1, JNK2 and JNK3 €120.00

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