Enzymes

A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].


[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

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Axon ID Name Description From price
2540 Akt Inhibitor VIII Inhibitor of Akt1 and 2 with significant off-side effects (CaMKIα and AhR) €125.00
2551 Alda 1 Small molecule activator of ALDH2 €65.00
2925 Alpelisib PI3K inhibitor (p110-α specific)  Recently added €90.00
2639 AMG 232 Potent, selective, and orally bioavailable MDM2-p53 inhibitor €115.00
1783 AMG 900 Aurora inhibitor (non-specific) €115.00
2863 AMI-1 Inhibitor of PRMT €99.00
1496 Aminobenzamide, 3- Competitive small molecule inhibitor of PARP €45.00
1066 Aminotetraline hydrobromide, N-Cyclopropyl-N-methyl-2- MAO inhibitor €95.00
1067 Aminotetraline hydrochloride, N-Cyclopropyl-2- MAO inhibitor Inquire
2368 Amuvatinib RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met €105.00
1490 Anacardic acid A HAT inhibitor €60.00
1857 AP 24534 BCR-ABL kinase inhibitor (including T315I mutation) €90.00
2137 APE1 Inhibitor III Inhibitor of apurinic/apyrimidinic endonuclease 1 (APE1) €105.00
1754 Apixaban Factor Xa inhibitor €125.00
2006 Apoptosis Activator 2 A cell-permeable apoptosis activator €75.00

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