Enzymes

A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].


[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

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Axon ID Name Description From price
2888 ABT 888 dihydrochloride PARP inhibitor  Recently added €95.00
2857 Acalisib PI3K inhibitor (p110 δ specific) €120.00
2083 ADAMTS-5 inhibitor Selective inhibitor of ADAMTS-5 (aggrecanase-2) €135.00
1291 AEG 3482 JNK inhibitor €85.00
1529 AG 014699 PARP1 inhibitor €75.00
1378 AG 490 JAK2 inhibitor €65.00
1571 AG 7088 HRV3C protease inhibitor €95.00
2746 AG-120 IDH1 mutant enzyme inhibitor €125.00
2745 AG-221 IDH2 mutant enzyme inhibitor €95.00
2122 AGI 5198 Inhibitor of R132 mutant isocitrate dehydrogenase 1 (IDH1) €75.00
2274 AGI 6780 Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q) €90.00
2389 AICAR Potent AMPK activator and inducer of differentiation of NSCs €45.00
2031 AIM 100 Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2) €95.00
2269 AK 1 Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 €90.00
2270 AK 7 Potent, brain-permeable and selective inhibitor of SIRT2 €90.00

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