A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].

[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

13 Item(s)

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Axon ID Name Description From price
2104 CP 471474 MMP inhibitor €95.00
2351 EHop 016 Rac GTPase inhibitor specific for Rac1 and Rac3 €85.00
2777 MBQ-167 Dual Rac and Cdc42 inhibitor €105.00
1578 NSC 23766 Rac1 inhibitor €110.00
2162 NSC 405020 MT1-MMP inhibitor specifically targeting PEX-domain. €85.00
2393 NSC 756093 Potent in vitro inhibitor of GBP1:PIM1 interaction €125.00
1271 PD 166793 MMP inhibitor €90.00
1181 PF 00356231 MMP-12 inhibitor €135.00
2328 PTIQ Neuroprotectant with attenuating effects on MMP-3 expression €125.00
2370 SB-3CT Potent and selective inhibitor of Gelatinases MMP-2 and MMP-9 €125.00
2111 UK 356618 Potent MMP-3 (aka Stromelysin-1) inhibitor €90.00
2073 UK 383367 Inhibitor of bone morphogenetic protein 1 (BMP-1, aka PCP) €80.00
2138 ZCL 278 Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction €105.00

13 Item(s)

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