A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].

[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

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Axon ID Name Description From price
2289 ABT 702 The first, non-nucleoside adenosine kinase (ADK) inhibitor €120.00
3144 Blebbistatin, (+)- Negative control of (±)-Blebbistatin as an inhibitor of class II myosins  Recently added €90.00
3074 Blebbistatin, (-)- Selective inhibitor of class II myosins; Active enantiomer of (±)-Blebbistatin  Recently added €90.00
2718 Blebbistatin, (±)- Potent and specific inhibitor of class II myosins €95.00
2684 CDN1163 Allosteric Activator of SERCA2b €90.00
1835 CK 1827452 Cardiac specific myosin ATPase activator €115.00
1826 DBeQ Inhibitor of p97 ATPase €90.00
1695 Digoxigenin bisdigitoxoside Metabolite of Digoxin €155.00
1649 Digoxin Na+/K+ ATPase pump inhibitor €75.00
3143 KUS121 ATPase inhibitor of valosin-containing protein (VCP)  Recently added €140.00
2664 LRE1 Allosteric soluble adenylyl cyclase (sAC) inhibitor €95.00
2683 MYK-461 Cardiac specific myosin ATPase inhibitor €135.00
2663 Rbin-1 Potent, reversible, and specific inhibitor of Midasin €125.00
2712 Rbin-2 Potent, reversible, and specific inhibitor of Midasin €95.00
1971 TAK 438 Potassium-competitive acid blocker (P-CAB) €145.00

15 Item(s)

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