Enzymes

A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].


[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

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Axon ID Name Description From price
1873 Abiraterone Inhibitor of CYP17A1 €90.00
1874 Abiraterone acetate Prodrug of Abiraterone; Inhibitor of CYP17A1 €90.00
1456 AZD 0530 difumarate Inhibitor of SRC and ABL tyrosine kinases €105.00
2097 CGP 77675 Src Family kinase (SFK) inhibitor €95.00
1941 MLR 1023 Selective allosteric activator of Lyn kinase €95.00
1892 NM-PP1, 1- Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) €95.00
1416 NVP-TAE684 NPM-ALK inhibitor €70.00
2026 PF 04981517 Inhibitor of Cytochrome P450 3A4 (CYP3A4) €110.00
2600 PF 06463922 Potent, orally available and brain-penetrant ALK/ROS1 selective inhibitor €105.00
1595 PPP hydrochloride CYP2B6 inhibitor €95.00
2778 Squarunkin A Selective UNC119–cargo interaction inhibitor €125.00
2743 STK16-IN-1 ATP-competitive STK16 inhibitor €125.00
1136 SU 6656 SRC kinase inhibitor €120.00
2922 Sulfaphenazole CYP2C9 inhibitor; Antibiotic €60.00
2124 TAK 700 Potent and highly selective inhibitor of 17,20-lyase (CYP17A1) €105.00

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