Enzymes

A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].


[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

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Axon ID Name Description From price
1909 A 1070722 Selective inhibitor of GSK-3 €95.00
1698 A 770041 Orally active src-family selective lck inhibitor €135.00
1857 AP 24534 BCR-ABL kinase inhibitor (including T315I mutation) €90.00
2167 AR-A 014418 ATP-competitive GSK-3 inhibitor €85.00
2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor €95.00
2005 ASP 3026 Inhibitor of the oncogenic fusion kinase EML4-ALK €80.00
2166 AT 13148 dihydrochloride ATP-competitive inhibitor of multi-AGC kinases €85.00
2669 AZ13705339 Potent and selective PAK1 inhibitor €125.00
2171 AZD 1080 Selective inhibitor of GSK-3α and GSK-3β €110.00
2795 AZD 1208 Pim kinase inhibitor €70.00
2194 AZD 2858 hydrochloride Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00
1693 BIO GSK-3 inhibitor €95.00
2798 BPKDi PKD inhibitor Inquire
2753 CCG 232601 Rho/MRTF/SRF transcriptional pathway inhibitor €160.00
1126 CHIR 98014 GSK-3 inhibitor €105.00

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