Enzymes

A fundamental task of proteins is to act as enzymes: catalysts that increase the rate of virtually all the chemical reactions within cells. They are highly selective, accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified as well. Cells contain thousands of different enzymes, and their activities determine which of the many possible chemical reactions actually take place within the cell. The binding of a substrate to the active site of an enzyme is a very specific interaction. Once a substrate is bound to the active site of an enzyme, multiple mechanisms can accelerate its conversion to the product of the reaction. Examples of enzymatic conversions of substrates include peptide bond formation or cleavage, hydrolysis and condensation, oxidation and reduction, phosphorylation, and many more. In addition to binding their substrates, the active sites of many enzymes bind other ions or small molecules that participate in catalysis. These molecules are called co-enzymes and/or co-factors. In contrast to substrates, coenzymes are not irreversibly altered by the reactions in which they are involved. While most enzymes move freely (intra- and extracellular) within the organism, many enzymes are anchored to either membranes or receptors[1]. The Axon Ligands™ that interact with enzymatic processes are arranged into the six major classes of enzymes in line with the rules of classification stated by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology[2].


[1] The Cell: A Molecular Approach. 2nd edition. Cooper GM. Sunderland (MA): Sinauer Associates; 2000.
[2] Enzyme Nomenclature 1992. Academic Press,San Diego,California, ISBN 0-12-227164-5.

Items 1 to 15 of 769 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Axon ID Name Description From price
2937 ZT-12-037-01 Specific STK19 inhibitor €95.00
1541 ZM 447439 Aurora B inhibitor €85.00
2445 ZLN 024 Allosteric activator of AMP-activated protein kinase (AMPK) €90.00
2878 ZL006 Selective inhibitor of the nNOS-PSD-95 interaction €105.00
1254 Zebularine DNA methyltransferase inhibitor €95.00
2138 ZCL 278 Cdc42 GTPase inhibitor, targeting Cdc42–ITSN interaction €105.00
1216 Zardaverine PDE3 and PDE4 inhibitor €75.00
2159 Z-VAD-FMK Pan-caspase inhibitor with in vivo activity Inquire
2674 YUKA1 Selective inhibitor of KDM5A demethylase €125.00
1685 YS 49 Antiplatelet, antithrombotic €135.00
2675 YMU1 Selective inhibitor of human thymidylate kinase (hTMPK) €110.00
2469 YK 4-279 Inhibitor of ETV1, ERG and interactions of EWS-FLI1 and RNA helicase A €95.00
1174 Y 700 Xanthine oxidase inhibitor €135.00
2911 Y 29794 tosylate Orally active, brain penetrant, potent and specific prolyl endopeptidase (PPCE) inhibitor €125.00
1683 Y 27632 dihydrochloride ROCK1 and ROCK2 inhibitor €65.00

Items 1 to 15 of 769 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Please wait...