GSTP
Glutathione S-transferase P1 (GSTP1 or GSTP-π; EC 2.5.1.18) is a member of a super-gene family of phase II metabolic enzymes, which are involved in conjugation reaction in phase II metabolism of xenobiotics. GSTP1 catalyzes the reactions between glutathione and a variety of potentially toxic and carcinogenic electrophilic compounds. Moreover, GSTs also play an important role in modulating the induction of other enzymes and proteins for cellular functions, such as DNA repair[1]. GSTP1 genetic polymorphism is being shown to be an important determinant not only of response to cancer chemotherapy but also of individual susceptibility to cancer[2]. More specifically, analyses of somatic genome alterations in prostatic carcinoma cells have revealed that somatic inactivation of GSTP1, may serve as an initiating genome lesion for prostatic carcinogenesis[3].
[1] Z. Mo et al. An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. Prostate. 2009 May 1;69(6):662-88.
[2] H.W. Lo et al. The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Res. 2004 Dec 15;64(24):9131-8.
[3] W.G. Nelson et al. The molecular pathogenesis of prostate cancer: Implications for prostate cancer prevention. Urology. 2001 Apr;57(4 Suppl 1):39-45.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| N0011 | Bequinostatin C | Glutathione S-Transferase (GST) π class inhibitor | Inquire | |
| N0010 | Bequinostatin A | Glutathione S-Transferase (GST) π class inhibitor | Inquire | |