Methyltransferases

Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].


[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159

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Axon ID Name Description From price
3750 GSK3326595 Orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5) Inquire
3919 GSK3368715 hydrochloride A first-in-class, orally active, potent and selective, SAM-Noncompetive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs) Inquire
3754 JNJ-64619178 dihydrochloride SAM-pocket binding (SAM Competitive) PRMT5 inhibitor Inquire
3796 MRTX1719 hydrochloride Inhibitor of the PRMT5.MTA complex Inquire
3798 PF-06855800 SAM-pocket-binding (SAM competitive) PRMT5 inhibitor Inquire

5 Item(s)

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