Methyltransferases
Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].
[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1254 | Zebularine | DNA methyltransferase inhibitor | €95.00 | |
3722 | Valemetostat | Inhibitor of Histone Lysine Methyltransferase EZH1/2 | €160.00 | |
4245 | UNC8732 | Highly potent second-generation NSD2 degrader | Recently added | €210.00 |
3592 | UNC7145 | Negative control of UNC6934 as a chemical probe targeting NSD2-PWWP1 | €90.00 | |
3591 | UNC6934 | Potent and selective chemical probe targeting NSD2-PWWP1 | €120.00 | |
4105 | UNC3474 maleate | 53BP1 antagonist | Recently added | €160.00 |
1840 | UNC0646 | Inhibitor of G9a/GLP Histone Lysine Methyltransferase | €99.00 | |
1889 | UNC0638 | Inhibitor of G9a (EHMT2)/GLP (EHMT1) | €85.00 | |
1841 | UNC0631 | Inhibitor of G9a/GLP Histone Lysine Methyltransferase | €99.00 | |
2418 | UNC0379 | Substrate competitive inhibitor of the H4K20 HMTase SETD8 | €125.00 | |
1789 | UNC0224 | Inhibitor of G9a HMTase | €85.00 | |
3993 | Tolcapone | Potent, selective, orally active and reversible COMT inhibitor | €70.00 | |
4279 | TAS-102 | TYMS inhibitor; Antimetabolite | €90.00 | |
3587 | STM2457 | First-in-class, highly potent and selective catalytic METTL3 inhibitor | €130.00 | |
5008 | Stem Cell RG-BIX inhibitor Set | Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively | €60.00 | |
2347 | SGI 1027 dihydrochloride | Inhibitor of DNMT activity in colon cancer cell lines | €110.00 | |
2945 | SGC707 | First-in-class, potent, selective and cell-active allosteric inhibitor of PRMT3 | €90.00 | |
2625 | SGC2085 | Potent and selective CARM1 inhibitor (aka PRMT4) | €120.00 | |
1691 | RG 108 | DNA methyltransferase inhibitor | €80.00 | |
2211 | PRMT3 inhibitor 1 | Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) | €105.00 | |
3692 | PF-06939999 dihydrochloride | SAM competitive PRMT5 inhibitor | Inquire | |
3798 | PF-06855800 | SAM-pocket-binding (SAM competitive) PRMT5 inhibitor | Inquire | |
3695 | PF-06821497 | Inhibitor of Histone Lysine Methyltransferase EZH2 | €160.00 | |
3162 | Pemetrexed disodium | Inhibitor of DHFR/TS/GARFT; Antifolate antimetabolite | €50.00 | |
2853 | Nolatrexed dihydrochloride | Water soluble inhibitor of thymidylate synthase | €120.00 | |
3469 | MS1943 trifluoroacetate | First-in-class EZH2 selective degrader; PROTAC | €200.00 | |
3681 | MS023 dihydrochloride | Potent, cell-active, and Type I selective PRMT inhibitor | €90.00 | |
3796 | MRTX1719 hydrochloride | Inhibitor of the PRMT5.MTA complex | Inquire | |
2223 | Lomeguatrib | Potent, orally active inhibitor of MGMT | €135.00 | |
3754 | JNJ-64619178 dihydrochloride | SAM-pocket binding (SAM Competitive) PRMT5 inhibitor | Inquire |