Methyltransferases

Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].


[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159

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Axon ID Name Description From price
1254 Zebularine DNA methyltransferase inhibitor €95.00
3722 Valemetostat Inhibitor of Histone Lysine Methyltransferase EZH1/2 €160.00
4245 UNC8732 Highly potent second-generation NSD2 degrader  Recently added €210.00
3592 UNC7145 Negative control of UNC6934 as a chemical probe targeting NSD2-PWWP1 €90.00
3591 UNC6934 Potent and selective chemical probe targeting NSD2-PWWP1 €120.00
4105 UNC3474 maleate 53BP1 antagonist  Recently added €160.00
1840 UNC0646 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
1889 UNC0638 Inhibitor of G9a (EHMT2)/GLP (EHMT1) €85.00
1841 UNC0631 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
2418 UNC0379 Substrate competitive inhibitor of the H4K20 HMTase SETD8 €125.00
1789 UNC0224 Inhibitor of G9a HMTase €85.00
3993 Tolcapone Potent, selective, orally active and reversible COMT inhibitor €70.00
4279 TAS-102 TYMS inhibitor; Antimetabolite €90.00
3587 STM2457 First-in-class, highly potent and selective catalytic METTL3 inhibitor €130.00
5008 Stem Cell RG-BIX inhibitor Set Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively €60.00
2347 SGI 1027 dihydrochloride Inhibitor of DNMT activity in colon cancer cell lines €110.00
2945 SGC707 First-in-class, potent, selective and cell-active allosteric inhibitor of PRMT3 €90.00
2625 SGC2085 Potent and selective CARM1 inhibitor (aka PRMT4) €120.00
1691 RG 108 DNA methyltransferase inhibitor €80.00
2211 PRMT3 inhibitor 1 Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) €105.00
3692 PF-06939999 dihydrochloride SAM competitive PRMT5 inhibitor Inquire
3798 PF-06855800 SAM-pocket-binding (SAM competitive) PRMT5 inhibitor Inquire
3695 PF-06821497 Inhibitor of Histone Lysine Methyltransferase EZH2 €160.00
3162 Pemetrexed disodium Inhibitor of DHFR/TS/GARFT; Antifolate antimetabolite €50.00
2853 Nolatrexed dihydrochloride Water soluble inhibitor of thymidylate synthase €120.00
3469 MS1943 trifluoroacetate First-in-class EZH2 selective degrader; PROTAC €200.00
3681 MS023 dihydrochloride Potent, cell-active, and Type I selective PRMT inhibitor €90.00
3796 MRTX1719 hydrochloride Inhibitor of the PRMT5.MTA complex Inquire
2223 Lomeguatrib Potent, orally active inhibitor of MGMT €135.00
3754 JNJ-64619178 dihydrochloride SAM-pocket binding (SAM Competitive) PRMT5 inhibitor Inquire

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