Methyltransferases

Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].


[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159

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Axon ID Name Description From price
1254 Zebularine DNA methyltransferase inhibitor €95.00
1840 UNC 0646 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
1889 UNC 0638 Inhibitor of G9a (EHMT2)/GLP (EHMT1) €85.00
1841 UNC 0631 Inhibitor of G9a/GLP Histone Lysine Methyltransferase €99.00
2418 UNC 0379 Substrate competitive inhibitor of the H4K20 HMTase SETD8 €125.00
1789 UNC 0224 Inhibitor of G9a HMTase €85.00
5008 Stem Cell RG-BIX inhibitor Set Set of RG 108 and BIX 01294 HCl, inhibitors of DNMT and HMTase, respectively €60.00
2347 SGI 1027 dihydrochloride Inhibitor of DNMT activity in colon cancer cell lines €110.00
2945 SGC707 First-in-class, potent, selective and cell-active allosteric inhibitor of PRMT3 €90.00
2625 SGC2085 Potent and selective CARM1 inhibitor (aka PRMT4) €120.00
1691 RG 108 DNA methyltransferase inhibitor €80.00
2211 PRMT3 inhibitor 1 Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) €105.00
3162 Pemetrexed disodium Inhibitor of DHFR/TS/GARFT; Antifolate antimetabolite €50.00
2853 Nolatrexed dihydrochloride Water soluble inhibitor of thymidylate synthase €120.00
2223 Lomeguatrib Potent, orally active inhibitor of MGMT €135.00

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