Methyltransferases
Over the recent years, Axon Medchem has significantly expanded its product line in the field of oncology research tools. Among them, the DNA methyltransferase and histone methyltransferase inhibitors comprise a small, yet significant selection of this set of tools. In view of the recent focus in biology on epigenetics, and DNA methylation being the best-known epigenetic marker (see also section: Axon Ligands™ for Epigenetic Research), we aim to be up front with these products to serve researchers in their objective to develop new drugs for the treatment of cancers and study the mechanisms involved in gene expression[1].
[1] Epigenetics in Cancer. M. Esteller.N Engl J Med 2008; 358, 1148-1159
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2705 | A-196 | Potent and selective inhibitor of SUV4-20 | €105.00 | |
2863 | AMI-1 | Inhibitor of PRMT | €99.00 | |
2635 | BAY-598 | Selective inhibitor of SMYD2 | €110.00 | |
2735 | BCI-121 | Inhibitor of SMYD3 | €90.00 | |
1692 | BIX 01294 trihydrochloride | HMTase inhibitor (G9a and G9a-like protein) | €80.00 | |
2210 | C 7280948 | Sulfone inhibitor of PRMT1 | €85.00 | |
3460 | Capecitabine | Oral prodrug of fluorouracil; TYMS inhibitor | €50.00 | |
2812 | CM-272 | First-in-class potent, selective and reversible inhibitor of G9a/DNMT | €130.00 | |
2709 | CMP5 | Inhibitor of PRMT5 | €95.00 | |
1590 | Decitabine | DNA methyltransferase inhibitor | €85.00 | |
2701 | EED226 | Potent, selective and orally bioavailable PRC2 inhibitor | €90.00 | |
3389 | Entacapone | Potent, peripherally acting, reversible COMT inhibitor | €50.00 | |
2831 | EPZ 015666 | Potent, selective and orally available inhibitor of PRMT5 | €125.00 | |
2227 | EPZ 6438 | Inhibitor of Histone Lysine Methyltransferase EZH2 | €80.00 | |
3960 | EPZ-5676 | Selective and S-adenosyl methionine (SAM) competitive inhibitor of DOT1L methyltransferase | Inquire | |
4137 | EPZ005687 hydrochloride | EZH2 HMTase inhibitor | Inquire | |
4216 | EPZ011989 hydrochloride | Cell permeable, metabolically stable and orally available EZH2 inhibitor | Inquire | |
3462 | Floxuridine | TYMS inhibitor; Antimetabolite | €50.00 | |
2140 | GSK 126 | Inhibitor of Histone Lysine Methyltransferase EZH2 | €75.00 | |
3900 | GSK-3484862 | No-covalent DNMT1-selective inhibitor | Inquire | |
3750 | GSK3326595 | Orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5) | Inquire | |
3919 | GSK3368715 hydrochloride | A first-in-class, orally active, potent and selective, SAM-Noncompetive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs) | Inquire | |
3757 | GSK3685032 hydrochloride | Potent first-in-class DNMT1-selective inhibitor | Inquire | |
2710 | HLCL65 hydrochloride | Inhibitor of PRMT5 | €105.00 | |
3754 | JNJ-64619178 dihydrochloride | SAM-pocket binding (SAM Competitive) PRMT5 inhibitor | Inquire | |
2223 | Lomeguatrib | Potent, orally active inhibitor of MGMT | €135.00 | |
3796 | MRTX1719 hydrochloride | Inhibitor of the PRMT5.MTA complex | Inquire | |
3681 | MS023 dihydrochloride | Potent, cell-active, and Type I selective PRMT inhibitor | €90.00 | |
2853 | Nolatrexed dihydrochloride | Water soluble inhibitor of thymidylate synthase | €120.00 | |
3162 | Pemetrexed disodium | Inhibitor of DHFR/TS/GARFT; Antifolate antimetabolite | €50.00 |