Kinases (Tyrosine Specific Protein)

Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.

[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.

16 Item(s)

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Axon ID Name Description From price
1698 A 770041 Orally active src-family selective lck inhibitor €140.00
2005 ASP 3026 Inhibitor of the oncogenic fusion kinase EML4-ALK €80.00
2992 CTx-0294885 Broad-spectrum kinase inhibitor €90.00
1392 Dasatinib Bcr-Abl and Src tyrosine kinase inhibitor €90.00
2574 Defactinib Orally available second generation inhibitor of FAK and PYK2 €80.00
3717 GSK2256098 FAK inhibitor Inquire
2121 INNO 406 Dual Bcr-Abl and Lyn kinase inhibitor €85.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €200.00
1623 PF 573228 FAK inhibitor €95.00
2459 PND 1186 Orally active dual FAK/PYK2 inhibitor triggering cell apoptosis in tumor cells €90.00
1407 SKI 606 Bcr-Abl and Src tyrosine kinase inhibitor €75.00
2130 Stem Cell Alternative 2i inhibitor Set Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) €110.00
2560 Tilfrinib Brk inhibitor with antiproliferative activity in breast tumor cells €95.00
3099 TL02-59 Potent, selective and orally active Fgr and Lyn inhibitor €120.00
2381 WH-4-023 Orally active src-family selective lck inhibitor €90.00
3973 XL-228 Multitargeted protein kinase inhibitor (IGF1R, Aurora,FGFR, ABL,ALK and SRC) Inquire

16 Item(s)

per page
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