Kinases (Tyrosine Specific Protein)

Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.

[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.

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Axon ID Name Description From price
3789 YH-306 FAK inhibitor €90.00
2762 XMD 8-87 Potent and selective inhibitor of Ack1 tyrosine kinase (also known as TNK2) €95.00
3973 XL-228 Multitargeted protein kinase inhibitor (IGF1R, Aurora,FGFR, ABL,ALK and SRC) Inquire
2231 XL 019 JAK2 inhibitor €100.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2381 WH-4-023 Orally active src-family selective lck inhibitor €90.00
2072 Tofacitinib citrate Potent Janus Kinase 3 (JAK3) inhibitor €115.00
3099 TL02-59 Potent, selective and orally active Fgr and Lyn inhibitor €120.00
2560 Tilfrinib Brk inhibitor with antiproliferative activity in breast tumor cells €95.00
1588 TG 101348 JAK2 inhibitor €80.00
3866 TAE226 Potent and ATP-competitive dual FAK and IGF-1R inhibitor €110.00
1136 SU 6656 SRC kinase inhibitor €120.00
2130 Stem Cell Alternative 2i inhibitor Set Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) €110.00
2778 Squarunkin A Selective UNC119–cargo interaction inhibitor €125.00
2539 Solcitinib Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases €90.00
1407 SKI 606 Bcr-Abl and Src tyrosine kinase inhibitor €75.00
3284 Saracatinib Inhibitor of SRC and ABL tyrosine kinases €70.00
1598 Ruxolitinib JAK1 and JAK2 inhibitor €65.00
3668 RP-6306 First-in-class, potent, selective, and orally bioavailable PKMYT1 inhibitor €140.00
3869 RN486 Selective and reversible inhibitor of Bruton's tyrosine kinase (BTK) Inquire
1674 R406 Spleen tyrosine kinase Inhibitor €80.00
2459 PND 1186 Orally active dual FAK/PYK2 inhibitor triggering cell apoptosis in tumor cells €90.00
4215 PF-562271 Potent, selective, ATP-competitive and reversible dual FAK/PYK2 inhibitor  Recently added €110.00
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
1623 PF 573228 FAK inhibitor €95.00
2107 PF 431396 Dual FAK(PTK2) and PYK2 inhibitor €80.00
2110 PF 06465469 Inhibitor of interleukin-2 inducible T cell kinase (ITK) €120.00
2023 PF 03814735 ATP-competitive inhibitor of aurora kinase A and B €120.00
3950 Peficitinib Potent and orally bioavailable JAK inhibitor €120.00
1858 PCI 32765 Inhibitor of Bruton's tyrosine kinase (BTK) €60.00

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