Kinases (Tyrosine Specific Protein)

Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.


[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.

23 Item(s)

per page
Axon ID Name Description From price
2231 XL 019 JAK2 inhibitor €100.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2072 Tofacitinib citrate Potent Janus Kinase 3 (JAK3) inhibitor €115.00
1588 TG 101348 JAK2 inhibitor €80.00
2539 Solcitinib Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases €90.00
1598 Ruxolitinib JAK1 and JAK2 inhibitor €65.00
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
3950 Peficitinib Potent and orally bioavailable JAK inhibitor €120.00
2792 NVP-BSK805 Potent, selective and orally bioavailable JAK2 inhibitor €125.00
4124 Momelotinib hydrochloride JAK1 and JAK2 inhibitor €120.00
1681 Momelotinib JAK1 and JAK2 inhibitor €80.00
2554 LY 2784544 Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F) €95.00
1843 JAK2 inhibitor 13 JAK2 inhibitor €110.00
4006 GLPG-0634 The first orally-available, selective inhibitor of JAK1 Inquire
4091 Deucravacitinib Potent, highly selective, allosteric and orally bioavailable TYK2 inhibitor €150.00
3861 Decernotinib Potent and selective,orally bioavailable Janus kinase 3 (JAK3) inhibitor Inquire
1338 CP 690550 JAK3 inhibitor €60.00
3671 CEP-33779 Potent, selective and orally bioavailable JAK2 inhibitor €95.00
3813 BMS-911543 Potent, selective and orally active inhibitor of JAK2 Inquire
1955 Baricitinib Inhibitor of JAK1 and JAK2 €70.00
3855 AZD-4205 Selective and ATP-competitive inhibitor of JAK1 Inquire
1778 AZ 960 JAK2 inhibitor €95.00
1378 AG 490 JAK2 inhibitor €65.00

23 Item(s)

per page
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