Kinases (Tyrosine Specific Protein)

Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.

[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.

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Axon ID Name Description From price
3759 (aR)-RP-6306 (aR)-enantiomer of RP-6306 (Axon 3668); PKMYT1 inhibitor €180.00
1892 1-NM-PP1 Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) €95.00
1698 A 770041 Orally active src-family selective lck inhibitor €140.00
4141 Acalabrutinib Orally active, irreversible, and highly selective second-generation BTK inhibitor Inquire
1378 AG 490 JAK2 inhibitor €65.00
2031 AIM 100 Specific inhibitor of Ack1 tyrosine kinase (also known as TNK2) €95.00
3997 ASN-002 Potent dual inhibitor of SYK and pan-JAK kinases Inquire
2005 ASP 3026 Inhibitor of the oncogenic fusion kinase EML4-ALK €80.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
2226 AVL 292 Potent, selective, covalent BTK inhibitor €110.00
1778 AZ 960 JAK2 inhibitor €95.00
3855 AZD-4205 Selective and ATP-competitive inhibitor of JAK1 Inquire
1456 AZD0530 difumarate Inhibitor of SRC and ABL tyrosine kinases €70.00
1955 Baricitinib Inhibitor of JAK1 and JAK2 €70.00
3813 BMS-911543 Potent, selective and orally active inhibitor of JAK2 Inquire
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor €80.00
3931 CEP-28122 Highly potent, selective and orally active ALK inhibitor Inquire
3671 CEP-33779 Potent, selective and orally bioavailable JAK2 inhibitor €95.00
2775 Cerdulatinib Orally active dual Syk/JAK inhibitor €85.00
2018 CGI 1746 Inhibitor of Bruton's tyrosine kinase (BTK) €50.00
2097 CGP 77675 Src Family kinase (SFK) inhibitor €65.00
1338 CP 690550 JAK3 inhibitor €60.00
1660 Crizotinib c-MET Inhibitor; NPM-ALK inhibitor €70.00
2992 CTx-0294885 Broad-spectrum kinase inhibitor €90.00
1392 Dasatinib Bcr-Abl and Src tyrosine kinase inhibitor €90.00
3861 Decernotinib Potent and selective,orally bioavailable Janus kinase 3 (JAK3) inhibitor Inquire
2574 Defactinib Orally available second generation inhibitor of FAK and PYK2 €80.00
4091 Deucravacitinib Potent, highly selective, allosteric and orally bioavailable TYK2 inhibitor €150.00
4006 GLPG-0634 The first orally-available, selective inhibitor of JAK1 Inquire
4153 GS-9973 Selective Syk inhibitor Inquire

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