Kinases (Serine-Threonine Specific Protein)

The reversible phosphorylation of proteins represents a major post-translational signaling mechanism and regulatory pathway that controls a diverse set of cellular processes. The mode of action of these protein kinases is the reversible hydroxyl-phosphorylation of tyrosine, serine, and/or threonine residues of protein substrates. Since most kinases are specifically targeting tyrosine substrates, or serine/threonine substrates, the Axon Ligands™ in this catalogue targeting kinases have been subdivided into the two corresponding classes.Moreover, often the protein kinase itself is the substrate for an upstream kinase or undergoes auto-phosphorylation as part of a cascade of protein kinase signaling within the cell. Some representative protein kinase signaling pathways within cells include growth factor signaling and stress-activated signaling responses. Such pathways are highly interconnected and complex and regulate numerous cellular functions such as gene transcription, cell growth, proliferation, and differentiation. Signaling pathways of interest that will be highlighted individually are the DNA-damage response, the PI3K/AKT/mTOR pathway, the MAPK/ERK pathway, the NF-κB pathway, the TGF-β pathway, and the Wnt/β-Catenin pathway. Aberrant protein kinase activity can disrupt the normal control of cellular phosphorylation signaling pathways and lead to tumor formation. Given the critical role that protein kinases have in modulating cellular functions such as tumorigenesis, this class of enzymes has been targeted for the discovery and design of biologics and small-molecule inhibitors as potential therapeutic agents[1].


[1] Therapeutic Protein Kinase Inhibitors. S. K. Grant. Cell. Mol. Life Sci. 2009, 66, 1163 – 1177. 

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Axon ID Name Description From price
1902 4μ8C IRE1α inhibitor €105.00
1399 AZD 7762 hydrochloride CHK inhibitor €60.00
1611 CGP 57380 Mnk1 inhibitor €95.00
1636 CHIR 124 CHK1 inhibitor €65.00
1495 CP 466722 ATM inhibitor €80.00
1656 Irestatin 9389 IRE1 inhibitor; UPR inhibitor €125.00
2604 KU 0060648 DNA-PK inhibitor €125.00
1584 KU 0060648 trihydrochloride DNA-PK inhibitor Inquire
1367 KU 55933 ATM inhibitor €125.00
3029 LDC000067 Potent, highly specific, ATP-competitive CDK9 inhibitor  Recently added €110.00
1463 NU 7441 DNA-PK inhibitor €55.00
1379 PF 477736 CHK1 inhibitor €70.00
2690 PHA-767491 Dual CDC7/CDK9 kinase inhibitor €95.00
2714 SPHINX31 Potent and selective inhibitor of SRPK1 kinase activity €125.00
2200 SRPIN 340 Selective ATP-competitive inhibitor of SRPK kinase activity €95.00

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