Kinases (Serine-Threonine Specific Protein)

The reversible phosphorylation of proteins represents a major post-translational signaling mechanism and regulatory pathway that controls a diverse set of cellular processes. The mode of action of these protein kinases is the reversible hydroxyl-phosphorylation of tyrosine, serine, and/or threonine residues of protein substrates. Since most kinases are specifically targeting tyrosine substrates, or serine/threonine substrates, the Axon Ligands™ in this catalogue targeting kinases have been subdivided into the two corresponding classes.Moreover, often the protein kinase itself is the substrate for an upstream kinase or undergoes auto-phosphorylation as part of a cascade of protein kinase signaling within the cell. Some representative protein kinase signaling pathways within cells include growth factor signaling and stress-activated signaling responses. Such pathways are highly interconnected and complex and regulate numerous cellular functions such as gene transcription, cell growth, proliferation, and differentiation. Signaling pathways of interest that will be highlighted individually are the DNA-damage response, the PI3K/AKT/mTOR pathway, the MAPK/ERK pathway, the NF-κB pathway, the TGF-β pathway, and the Wnt/β-Catenin pathway. Aberrant protein kinase activity can disrupt the normal control of cellular phosphorylation signaling pathways and lead to tumor formation. Given the critical role that protein kinases have in modulating cellular functions such as tumorigenesis, this class of enzymes has been targeted for the discovery and design of biologics and small-molecule inhibitors as potential therapeutic agents[1].


[1] Therapeutic Protein Kinase Inhibitors. S. K. Grant. Cell. Mol. Life Sci. 2009, 66, 1163 – 1177. 

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Axon ID Name Description From price
1291 AEG 3482 JNK inhibitor €85.00
2002 AS 602801 JNK inhibitor, which inhibited JNK1, JNK2 and JNK3 €120.00
2179 ASK1 Inhibitor 10 Potent, selective, and orally bioavailable ASK1 inhibitor €125.00
1358 BIRB 796 MAPK inhibitor (p38 specific) €65.00
1808 BIX 02188 MEK5 inhibitor; ERK5 inhibitor €125.00
1809 BIX 02189 MEK5 inhibitor; ERK5 inhibitor €125.00
2856 BMS 582949 Inhibitor of p38α MAPK €155.00
2025 CC-401 ATP-competitive JNK inhibitor €115.00
2634 CC-930 Potent, selective, and orally active anti-fibrotic JNK inhibitor €105.00
1694 FR 180204 ERK inhibitor; AP-1 inhibitor €95.00
2361 JNK-IN-8 Remarkably potent and selective covalent inhibitor of JNK €120.00
1895 LY 2228820 Inhibitor of p38 MAPK €105.00
2366 NG 25 trihydrochloride Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) €85.00
1814 NQDI 1 Inhibitor of apoptosis signal-regulating kinase 1 (ASK1) €115.00
1365 PD 169316 MAPK inhibitor (p38 specific) €50.00

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