IRAK
The interleukin-1 receptor-associated kinase (IRAK) family mediates activating signal from TLRs and interleukin-1 receptor. The family comprises of four members, IRAK1, IRAK2, IRAK-M, IRAK4. The family members have a role in either positive or negative regulation of innate immunity, adaptive immunity and inflammation. Accumulated evidence proves that IRAK performs significantly in the pathogenesis of inflammatory autoimmune disorders.[1] Moreover, mounting evidence implicates these kinases as viable cancer targets.[2]
[1] LC Su et al. IRAK family in inflammatory autoimmune diseases. Autoimmun Rev. 2020 Mar;19(3):102461.
[2] GW Rhyasen et al. IRAK signalling in cancer. Br J Cancer. 2015 Jan 20;112(2):232-7.