Aurora
The Aurora kinase family (EC 2.7.11.1) is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis, essential for accurate and equal segregation of genomic material from parent to daughter cells. As a result, they play a central role in cell cycle regulation[1]. Three related kinases known as Aurora-A, Aurora-B, and Aurora-C have been characterized over the years. Despite significant sequence homology, the localization and functions of these kinases are largely distinct from one another. Given the association of Aurora over-expression and tumorigenesis, these kinases have been targeted for cancer therapy, and a new class of drugs known as Aurora kinase inhibitors has been developed[2],[3].
[1] Mitotic kinases as regulators of cell division and its checkpoints. E.A. Nigg. Nat. Rev. Mol. Cell Biol. 2001, 2, 21–32.
[2] Aurora kinases. V.M. Bolanos-Garcia. Int. J. Biochem. & Cell Biol. 2005, 37, 1572–1577.
[3] Aurora Kinases: New Targets for Cancer Therapy. R.D. Carvajal, A. Tse, G.K. Schwartz. Clin. Cancer Res. 2006, 12, 6869.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3758 | LY-3295668 | Orally available, potent and highly selective Aurora A kinase (AurA) inhibitor | Inquire | |
| 3920 | GSK1070916 | Potent, selective and ATP competitive inhibitor of Aurora B and C kinases | €110.00 | |
| 4073 | CYC-116 | Aurora kinases A & B and VEGFR2 inhibitor | Inquire | |