PI3K

Another significantly large group of kinases that regulate the transfer phosphate groups to hydroxyl groups of substrates is the class of PI3K’s (Phosphatidylinositide 3-kinases, EC 2.7.1.153), a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The family may be divided into three different classes (I-III), based on primary structure, regulation, and in vitro lipid substrate specificity[1]. PI3K’s play a crucial role in the PI3K/AKT/mTOR signaling pathway which is strongly involved in the fundamental cellular processes of protein synthesis and apoptosis. Disturbed activation of this intracellular pathway has been associated with the development of diseases such as cancer, diabetes mellitus, and autoimmunity[2]. Upon activation of phosphatidylinositol (PI)-3-kinase by extracellular growth factors, phosphorylation of the inner membrane phosphoinositides activates AKT (also known as Protein Kinase B, PKB) and PDPK1 (3-phosphoinositide dependent protein kinase-1).


[1] PI3K/Akt/mTOR pathway as a target for cancer therapy. D. Morgensztern, H.L. McLeod Drugs 2005, 16, 797–803
[2] PI3K-Akt pathway: its functions and alterations in human cancer. Osaki M, Oshimura M, Ito H. Apoptosis 2004, 9, 667-676.

Items 1 to 30 of 50 total

per page
Page:
  1. 1
  2. 2
Axon ID Name Description From price
1831 A 66 PI3K inhibitor (p110-α specific) €95.00
2857 Acalisib PI3K inhibitor (p110 δ specific) €120.00
2925 Alpelisib PI3K inhibitor (p110-α specific) €90.00
3827 AMG-511 Orally bioavailable, highly potent and selective pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor Inquire
1424 AS 252424 PI3K inhibitor (p110-γ specific) €85.00
1436 AS 252424 bispotassium salt PI3K inhibitor (p110-γ specific) €95.00
2748 Autophinib PIK3C3/Vps34 inhibitor €120.00
3808 AZD3458 Orally bioavailable potent and selective PI3Kγ inhibitor Inquire
2926 AZD6482 PI3K inhibitor (p110 β specific) €120.00
3690 AZD8186 PI3Kβ/δ isoform-selective inhibitor Inquire
3055 B591 Potent, specific class I PI3K inhibitor €125.00
1282 BAG 956 PI3K and PDPK1 inhibitor €95.00
1281 BEZ 235 PI3K and mTOR tyrosine kinase inhibitor €50.00
2170 CAL 101 PI3K inhibitor (p110 δ specific) €95.00
2039 CZC 24832 PI3K inhibitor (p110-γ specific) €95.00
1719 D 106669 Potent and selective PI3K inhibitor €85.00
1377 GDC 0941 bismesylate PI3K inhibitor €80.00
1782 GDC 0980 Dual PI3K and mTOR inhibitor €80.00
2994 GNE 317 Brain-penetrant PI3K inhibitor (p110-α specific) €85.00
3807 GS-9901 Potent and isoform-selective inhibitor of PI3Kδ Inquire
1596 GSK 2126458 Dual PI3K and mTOR inhibitor €50.00
1912 GSK 2636771 dihydrochloride PI3K inhibitor (p110 β specific) €105.00
2168 IC 87114 Potent and highly selective inhibitor of the PI3K p110δ €85.00
4133 IPI-145 PI3K p110α/γ isoform specific inhibitor Inquire
4147 IPI-549 Orally bioavailable potent and selective PI3Kγ inhibitor Inquire
2869 LX2343 BACE 1 inhibitor €125.00
1366 LY 294002 PI3K inhibitor €70.00
3098 ME-401 Potent, selective and orally available PI3K inhibitor (p110 δ specific) €100.00
3247 Miltefosine PI3K/Akt inhibitor €50.00
1520 NVP-BBD130 Dual PI3K and mTOR kinase inhibitor €125.00

Items 1 to 30 of 50 total

per page
Page:
  1. 1
  2. 2
Please wait...