Glycosyltransferases

Glycosyltransferases catalyze glycosidic bond formation using sugar donors containing a nucleoside phosphate or a lipid phosphate leaving group. Two structural folds, GT-A and GT-B, have been identified for the nucleotide sugar-dependent enzymes, but other folds are now appearing for the soluble domains of lipid phosphosugar-dependent glycosyl transferases. Donor sugar substrates are most commonly activated in the form of nucleoside diphosphate sugars (e.g., UDP Gal, GDPMan); however, nucleoside monophosphate sugars (e.g., CMP NeuAc), lipid phosphates (e.g., dolichol phosphate oligosaccharides), and unsubstituted phosphate are also used. Nucleotide sugar-dependent glycosyltransferases are often referred to as Leloir enzymes. The acceptor substrates utilized by glycosyltransferases are most commonly other sugars but can also be a lipid, protein, nucleic acid, antibiotic, or another small molecule. Glycosyl transfer most frequently occurs to the nucleophilic oxygen of a hydroxyl substituent of the acceptor. However, it can also occur to nitrogen, sulfur, and carbon nucleophiles[1].


[1] L.L. Lairson et al. Glycosyltransferases: Structures, Functions, and Mechanisms. Ann. Rev. Biochem. 2008, 77, 521-555.

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Axon ID Name Description From price
1527 XAV 939 Tankyrase (TNKS) inhibitor €80.00
2369 UPF 1069 PARP-2 inhibitor with >26 fold selectivity over PARP1 €75.00
2502 Talazoparib Potent, selective, and orally available PARP1/2 inhibitor €105.00
2253 STF 118804 Highly specific, next-generation NAMPT inhibitor €120.00
2602 P7C3 Proneurogenic and neuroprotective compound that activates NAMPT €105.00
2599 NVP-TNKS656 Selective and orally active TNKS inhibitor and antagonist of Wnt pathway activity €95.00
1370 NU 1025 PARP inhibitor €80.00
2759 ME0328 PARP3/ARTD3 inhibitor €95.00
2001 KU 0058948 hydrochloride Potent and specific PARP1 inhibitor €135.00
1922 JW 55 Inhibitor of tankyrase (TNKS 1 and 2) €95.00
2510 IWR-1-endo Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 €85.00
2537 Isoquinolinediol, 1,5- PARP1 inhibitor and neuroprotective agent €50.00
1566 Iniparib PARP inhibitor €65.00
1546 FK 866 hydrochloride NAMPT inhibitor €90.00
1279 FK 866 NAMPT inhibitor; NAD biosysthesis inhibitor €90.00

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