The class of acylgroup transferring enzymes includes a multitude of substrate specific enzymes. For example, diacylglycerol O-acyltransferase 1 (DGAT1; EC catalyzes the final step of the synthesis of triglycerides (TG) and plays a critical role in dietary fat absorption in the small intestine. Therefore, it is a potential therapeutic target for treatment of obesity and related metabolic diseases[1]. The co-enzyme Acyl-CoA is the donor substrate of the acetyl group that is transferred to the diglyceride substrates of DGAT1.

[1] Y. Hiramine, T. Tanabe. Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine. J. Physiol. Biochem. 2011, 67, 259-264.

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2042 Azithromycin Macrolide antibiotic; Binds the 50S ribosomal subunit €50.00
3445 Clarithromycin Macrolide antibiotic; Binds the 50S ribosomal subunit  Recently added €50.00
2063 Clindamycin Inhibitor of peptidyl transferase; Antibiotic €75.00
2510 IWR-1-endo Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 €85.00
2048 Linezolid Protein synthesis inhibitor; antibiotic €80.00
1762 PNU 100480 Ribosomal peptidyl transferase center (PTC) inhibitor €60.00
2606 Solithromycin Fluoroketolide antibiotic €135.00

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