Desaturases

Long-chain polyunsaturated fatty acids (PUFA) of the ω3- and ω6-series are essential for a number of cellular functions such as maintaining membrane fluidity, providing substrates for eicosanoid signaling, modification of ion channels and regulation of gene expression. In view of that, these fatty acids are involved in several such basic cellular mechanisms, it is not surprising that they influence a number of physiological processes and have been implicated in such diverse conditions as cardiovascular disease, inflammatory diseases, osteoporosis and depression[1]. Both Axon 2091 and Axon 2112 are selective inhibitors of these fatty acid converting enzymes (SCD1 and FADS2 or Δ6-desaturase; EC 1.14.19.1.).


[1] Relationship of Δ6-desaturase and Δ5-desaturase activities with thyroid hormone status in adolescents with eating disorders and weight loss. I. Swenne, B. Vessby. Act. Pædiatrica 2013, 102, 416-418,

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Axon ID Name Description From price
2112 SC 26196 Selective Δ6-desaturase inhibitor €85.00
2091 PluriSIn #1 Inhibitor of stearoyl-coA desaturase (SCD1) €75.00

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