Dehydrogenase (11β-hydroxysteroid, type 1)

Two 11β-hydroxysteroid dehydrogenases (11β-HSD; EC 1.1.1.146) catalyze the interconversion between active and inactive glucocorticoids. The enzyme 11β-HSD1 is widely expressed and yields increased local tissue concentration of active glucocorticoid by converting cortisone into cortisol in humans, and 11-dehydrocorticosterone into corticosterone in rodents. In contrast, the enzyme 11β-HSD2 catalyzes the opposite reaction, the inactivation of active glucocorticoid. 11β-HSD1 has been proposed as a new target for type 2 diabetes drugs, since they lower blood glucose levels and improve insulin sensitivity[1].


[1] P. Alberts et al. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003, 144(11), 4755-4762.

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Axon ID Name Description From price
1756 BVT 2733 hydrochloride Inhibitor of 11β-hydroxysteroid dehydrogenase type 1 €115.00
9999 Faketone Inactive test €0.01

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