Dehydrogenase (11β-hydroxysteroid, type 1)
Two 11β-hydroxysteroid dehydrogenases (11β-HSD; EC 184.108.40.206) catalyze the interconversion between active and inactive glucocorticoids. The enzyme 11β-HSD1 is widely expressed and yields increased local tissue concentration of active glucocorticoid by converting cortisone into cortisol in humans, and 11-dehydrocorticosterone into corticosterone in rodents. In contrast, the enzyme 11β-HSD2 catalyzes the opposite reaction, the inactivation of active glucocorticoid. 11β-HSD1 has been proposed as a new target for type 2 diabetes drugs, since they lower blood glucose levels and improve insulin sensitivity.
 P. Alberts et al. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003, 144(11), 4755-4762.