Hydrolases

The group of hydrolases (EC 3.-.-.-) consists of 13 subgroups, as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. Only few of them are represented in the Axon Ligands™ catalogue. The enzymes that catalyze the hydrolysis of various bonds are classified by the nature of the chemical bonds they cleave. Examples of enzymes of this group of enzymes are esterases, peptidases, and deacetylases.

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Axon ID Name Description From price
1810 Bortezomib Inhibitor of 26S proteasome €85.00
1798 Eeyarestatin I Inhibitor of endoplasmic reticulum associated protein degradation (ERAD) €80.00
2449 LDN 57444 Reversible, competitive inhibitor of UCH-L1 deubiquitinase €95.00
1869 MG 132 Inhibitor of 26S proteasome €95.00
2309 ML 323 Selective, reversible and potent inhibitor of the USP1–UAF1 deubiquitinase complex €95.00
2995 ML 367 Inhibitor of ATAD5 stabilization  Recently added €125.00
2678 ML364 Inhibitor of the deubiquitinase USP2 €125.00
2556 MLN 2238 Selective and reversible 20S proteasome inhibitor €85.00
2557 MLN 9708 Citrate prodrug of MLN 2238, selective and reversible 20S proteasome inhibitor €95.00
2228 NSC 687852 Inhibitor of 19S regulatory-particle–associated deubiquitinases (DUBs: UCHL5 and USP14) €90.00
2199 ONX 0914 Selective inhibitor of LMP7 subunit of the immunoproteasome. €95.00
2011 P 005091 Inhibitor of deubiquitinase USP7 and USP47 €95.00
1906 P 22077 Inhibitor of deubiquitinase USP7 and USP47 €95.00
2512 Spautin 1 Inhibitor of USP10 and USP13 and Beclin1 related autophagy €95.00
2333 TCID Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1 €80.00

Items 1 to 15 of 17 total

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