Proteases (Serine)
The large family of serine proteases (almost one-third of all proteases; EC 3.4.21.-) is characterized by its general mechanism of action to cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. The members of this family can be divided roughly into four sub-groups based on their structure, being chymotrypsin-like (trypsin-like), subtilisin-like, carboxypeptidase Y-like, and Clp-like[1].
[1] L. Hedstrom. Serine Protease Mechanism and Specificity. Chem. Rev. 2002, 102, 4501-4524.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2911 | Y 29794 tosylate | Orally active, brain penetrant, potent and specific prolyl endopeptidase (PPCE) inhibitor | €125.00 | |
| 3173 | Velpatasvir | Hepatitis C virus NS5A inhibitor | €50.00 | |
| 1269 | SSR 69071 | HLE inhibitor | €145.00 | |
| 3175 | Rivaroxaban | Highly potent, selective and oral direct FXa inhibitor | €70.00 | |
| 1536 | Odiparcil | Thrombin inhibitor (via Heparin CoFII) | €140.00 | |
| 3300 | Ledipasvir | Potent and orally available NS5A inhibitor | €95.00 | |
| 2364 | GW 311616A | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor | €120.00 | |
| 3116 | Edoxaban tosylate | Potent, selective and orally active factor Xa inhibitor | €100.00 | |
| 1669 | Danoprevir | HCV NS3/4A serine protease inhibitor | €90.00 | |
| 2093 | Daclatasvir dihydrochloride | Hepatitis C virus (HCV) NS5A protein inhibitor | €70.00 | |
| 3117 | Dabigatran etexilate | Prodrug of Dabigatran; Thrombin inhibitor | €70.00 | |
| 2822 | BAY-678 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor | €105.00 | |
| 1754 | Apixaban | Factor Xa inhibitor | €95.00 | |