Proteases (Serine)
The large family of serine proteases (almost one-third of all proteases; EC 3.4.21.-) is characterized by its general mechanism of action to cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. The members of this family can be divided roughly into four sub-groups based on their structure, being chymotrypsin-like (trypsin-like), subtilisin-like, carboxypeptidase Y-like, and Clp-like[1].
[1] L. Hedstrom. Serine Protease Mechanism and Specificity. Chem. Rev. 2002, 102, 4501-4524.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2911 | Y 29794 tosylate | Orally active, brain penetrant, potent and specific prolyl endopeptidase (PPCE) inhibitor | €125.00 | |
| 3173 | Velpatasvir | Hepatitis C virus NS5A inhibitor | €50.00 | |
| 3618 | uPA inhibitor BC-11 hydrobromide | Highly specific urokinase-plasminogen activator (uPa) inhibitor | €115.00 | |
| 2734 | TM 5441 | Orally active inhibitor of PAI-1 | €105.00 | |
| 2344 | TM 5275 | Selective and orally active inhibitor of PAI-1 | €105.00 | |
| 1383 | Tiplaxtinin | Plasminogen activator inhibitor-1 (PAI-1) inhibitor | €70.00 | |
| 1769 | T 1776Na | Inhibitor of plasminogen activator inhibitor-1 | €80.00 | |
| 1269 | SSR 69071 | HLE inhibitor | €145.00 | |
| 2838 | SK-216 | Specific inhibitor of PAI-1 | €105.00 | |
| 3175 | Rivaroxaban | Highly potent, selective and oral direct FXa inhibitor | €70.00 | |
| 3875 | PCI-27483 | PCI-27483 is a potent and selective small-molecule inhibitor of activated factor VII (factor VIIa) | Inquire | |
| 3710 | PAZ-417 | Potent, orally active and CNS-penetrant PAI-1 inhibitor | €130.00 | |
| 1536 | Odiparcil | Thrombin inhibitor (via Heparin CoFII) | €140.00 | |
| 3300 | Ledipasvir | Potent and orally available NS5A inhibitor | €95.00 | |
| 3294 | HSP47 inhibitor III | Inhibitor of the collagen-specific chaperone HSP47 | €120.00 | |
| 2364 | GW 311616A | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor | €120.00 | |
| 3116 | Edoxaban tosylate | Potent, selective and orally active factor Xa inhibitor | €100.00 | |
| 1669 | Danoprevir | HCV NS3/4A serine protease inhibitor | €90.00 | |
| 2093 | Daclatasvir dihydrochloride | Hepatitis C virus (HCV) NS5A protein inhibitor | €70.00 | |
| 3117 | Dabigatran etexilate | Prodrug of Dabigatran; Thrombin inhibitor | €70.00 | |
| 3568 | Col003 | Potent, competitive collagen-Hsp47 interaction inhibitor | €110.00 | |
| 2822 | BAY-678 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor | €105.00 | |
| 1754 | Apixaban | Factor Xa inhibitor | €95.00 | |
| 3590 | ACT001 | PAI-1 inhibitor | €210.00 | |