Proteases (Metallo-)

Matrix metalloproteinases (MMPs; EC 3.4.24.-), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodeling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. The activities of most matrixins are very low or negligible in the normal steady-state tissues, but expression is transcriptionally controlled by inflammatory cytokines, growth factors, hormones, cell–cell and cell–matrix interaction. MMPs are classified as the matrixin subfamily of zinc metalloprotease family (M10)[1].


[1] H. Nagase, R. Visse, G. Murphy. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res. 2006, 69, 562-573.

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2083 ADAMTS-5 inhibitor Selective inhibitor of ADAMTS-5 (aggrecanase-2) €135.00

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