TNF-α converting enzyme (TACE or ADAM17; EC 3.4.24.86), a pro-inflammatory cytokine, catalyzes the formation of TNF-α from membrane bound TNF-α precursor protein. It is is believed to play pathophysiological roles in inflammation, anorexia, cachexia, septic shock, viral replication and so on. What’s more, TNF-α is a key player in inflammation and joint damage in rheumatoid arthritis. To control the level of TNF-α release, inhibition of TACE activity has long been considered as a promising way of treating related inflammatory diseases for which one of the most attractive strategies is the development of low molecular mass inhibitors of TACE[1].

MMP subclasses listed: MMP (PCP), MMP-2, MMP-3, MMP-9, MMP-12, MMP-13, MMP-14, ADAMTS-5, TACE