MALT1

Mucosa-associated-lymphoid-tissue (MALT1; EC 3.4.22.xx) cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. The caspase-like domain of MALT1 cleaves substrates following arginine residues, unlike conventional caspase that cleave after aspartate residues. MALT1 cleaves and disables A20 (TNFAIP3) and CYLD, both negative regulators of NF-κB, thereby potentiating NF-κB signaling[1].  


[1] R.M. Young et al. A New “Brew” of MALT1 Inhibitors. Cancer Cell, 2012, 22(6), 706-707.

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Axon ID Name Description From price
2193 Thioridazine hydrochloride DA and α1 adrenoceptor antagonist; MALT1 inhibitor €50.00
2054 MALT1 inhibitor MI-2 Highly potent and selective MALT1 inhibitor €125.00

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