LTA4H
Leukotriene A4 hydrolase/aminopeptidase (LTA4H; EC 3.3.2.6) is a ubiquitously expressed bifunctional zinc metalloenzyme with epoxide hydrolase and aminopeptidase activities utilizing the same Zn present active site. It catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate[1],[2].
[1] S. Thangapandian et al. Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design. PLoS One. 2012, 7, e34593.
[2] A.M. Fourie. Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. Curr. Opin. Investig. Drugs. 2009, 10, 1173-1182.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2307 | ARM1 hydrobromide | Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4 | €92.00 | |