Rab7

Rab7 (EC 3.6.5.2)  belongs to the superfamily of Ras small GTPases and is a regulator of intracellular endocytic/membrane trafficking. Additionally, it has been indicated that Rab proteins also regulate cell signalling, cell growth, cell survival and development. Rab proteins and their associated regulators or effectors have been implicated in many diseases, such as cancer, pigmentation disorder, neuropathy and lipid metabolism disorders. Rab7, with one of its effectors, RILP (Rab7-interacting lysosomal protein), recruit the dynein-dynactin motor complex to lysosomes facilitating lysosome trafficking along microtubules towards the cell nucleus. Moreover, in addition to its recognized role in vesicle trafficking, Rab7 has recently garnered attention as a regulator of apoptosis in response to growth factor withdrawal and has been proposed to function as a tumor suppressor protein[1],[2].

RAS GTPases listed: HRAS, Rab7, Rac


[1] J.J. Steffan et al. Supporting a role for the GTPase Rab7 in prostate cancer progression. PLoS One. 2014, 9, e87882.
[2] A.L. Edinger. Growth factors regulate cell survival by controlling nutrient transporter expression. Biochem. Soc. Trans. 2005, 33, 225-227.

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Axon ID Name Description From price
2184 CID 1067700 First inhibitor of Rab7 GTPase €125.00

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