SHP-2 (EC; aka tyrosine-protein phosphatase non-receptor type 11 (PTPN11), protein-tyrosine phosphatase 1D (PTP-1D), or protein-tyrosine phosphatase 2C (PTP-2C)) is a cytoplasmic SH2 (Src-homology 2) domain containing member of the family of protein tyrosine phosphatases (PTP), transducing signal relay from the cell surface to the nucleus[1]. It is ubiquitously expressed and shown to be involved in regulation of cellular development and differentiation, survival, and migration by promoting growth factors-induced activation of PI3K/Akt, the extracellular signal-related kinases (ERKs), NF-κB, JAK2/STAT, and other pathways[2].

[1] CK Qu. The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions. Cell Res. 2000 Dec;10(4):279-88.
[2] J Kiyan et al. The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells. Exp Cell Res. 2009 Apr 1;315(6):1029-39.

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3767 GDC-1971 Orally available, potent, and selective inhibitor of the protein tyrosine phosphatase SHP2 Inquire
3903 IACS-13909 hydrochloride Potent and specific allosteric inhibitor of SHP2 Inquire
3868 RMC-4550 hydrochloride Potent, selective and orally available small molecule allosteric inhibitor of SHP2 Inquire
3865 TNO155 Selective and orally bioavailable allosteric inhibitor of SHP2 Inquire

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