SHP
SHP-2 (EC 3.1.3.48; aka tyrosine-protein phosphatase non-receptor type 11 (PTPN11), protein-tyrosine phosphatase 1D (PTP-1D), or protein-tyrosine phosphatase 2C (PTP-2C)) is a cytoplasmic SH2 (Src-homology 2) domain containing member of the family of protein tyrosine phosphatases (PTP), transducing signal relay from the cell surface to the nucleus[1]. It is ubiquitously expressed and shown to be involved in regulation of cellular development and differentiation, survival, and migration by promoting growth factors-induced activation of PI3K/Akt, the extracellular signal-related kinases (ERKs), NF-κB, JAK2/STAT, and other pathways[2].
[1] CK Qu. The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions. Cell Res. 2000 Dec;10(4):279-88.
[2] J Kiyan et al. The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells. Exp Cell Res. 2009 Apr 1;315(6):1029-39.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2723 | TPI-1 | Selective SHP1 inhibitor | €95.00 | |
| 3865 | TNO155 | Selective and orally bioavailable allosteric inhibitor of SHP2 | Inquire | |
| 2633 | SHP099 | Highly potent, selective and orally bioavailable SHP2 inhibitor | €80.00 | |
| 3868 | RMC-4550 hydrochloride | Potent, selective and orally available small molecule allosteric inhibitor of SHP2 | Inquire | |
| 3721 | JAB-3068 | SHP2 inhibitor | €240.00 | |
| 3903 | IACS-13909 hydrochloride | Potent and specific allosteric inhibitor of SHP2 | Inquire | |
| 3767 | GDC-1971 | Orally available, potent, and selective inhibitor of the protein tyrosine phosphatase SHP2 | Inquire | |
| 3729 | ABBV-CLS-484 hydrochloride | Inhibitor of phosphatase PTPN1/N2 (Protein Tyrosine Phosphatase Non-Receptor Type 1 and 2), | Inquire | |