PPP1R15B
In mammals, two heterodimeric eIF2α holophosphatases maintain low levels of eIF2α phosphorylation: each comprises a regulatory subunit, the stress-inducible PPP1R15A (R15A), or the constitutive PPP1R15B (R15B), which is bound to the catalytic subunit protein phosphatase 1 (PP1c). This regulatory subunit of protein phosphatase 1, R15B, is a negative regulator of proteostasis.[1]
[1] A. Krzyzosiak et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3004 | Raphin1 | Selective, brain-penetrant, and orally bioavailable inhibitor of PPP1R15B (R15B) | €105.00 | |
| 2983 | Raphin1 acetate | Selective, brain-penetrant, and orally bioavailable inhibitor of PPP1R15B (R15B) | €110.00 | |