PPP1R15B

In mammals, two heterodimeric eIF2α holophosphatases maintain low levels of eIF2α phosphorylation: each comprises a regulatory subunit, the stress-inducible PPP1R15A (R15A), or the constitutive PPP1R15B (R15B), which is bound to the catalytic subunit protein phosphatase 1 (PP1c). This regulatory subunit of protein phosphatase 1, R15B, is a negative regulator of proteostasis.[1]


[1] A. Krzyzosiak et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.

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Axon ID Name Description From price
2983 Raphin1 acetate Selective, brain-penetrant, and orally bioavailable inhibitor of PPP1R15B (R15B) €110.00
3004 Raphin1 Selective, brain-penetrant, and orally bioavailable inhibitor of PPP1R15B (R15B) €105.00

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