No less than eleven sub-types of the enzyme family of phosphodiesterases (PDE; EC 3.1.4.-) are known to date, many of which exist as splice variants[1]. They are essential regulators of cyclic nucleotide signaling with diverse physiological functions. Roughly, the sub-types can be divided into 3 groups: one group of enzymes specifically degrades cyclic adenosine monophosphate (cAMP; PDE4, 7 and 8), another group specifically targets cyclic guanosine monophosphate (cGMP; PDE5, 6, and 9), whereas the third group of enzymes (including PDE1, 2, 3, 10, and 11) are non specific towards either cAMP or cGMP. PDEs influence a vast array of pharmacological processes, including pro-inflammatory mediator production and action, ion channel function, muscle contraction, learning, differentiation, apoptosis, lipogenesis, glycogenolysis and gluconeogenesis. Recent advances in molecular pharmacology of PDE isoenzymes resulted in identification of new potential applications of PDE inhibitors in various therapeutic areas, including dementia, depression and schizophrenia[2].

Phosphodiesterases listed: PDE, PLC, PLD

[1] Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. Bolger G. B. Cell. Signal. 1994, 6,  851–859.
[2] Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development. Y. H. Jeon,Y. -S. Heo, C. M. Kim,Y. -L. Hyun, T. G. Lee, S. Ro and J. M. Cho. Cell. Mol. Life Sci. Vol. 2005, 62, 1198.

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Axon ID Name Description From price
1229 (R)-(-)-Rolipram PDE4 inhibitor €110.00
1432 (S)-(+)-Rolipram PDE4 inhibitor €115.00
1957 Apremilast PDE4 inhibitor €60.00
1178 BAY 19-8004 PDE4 inhibitor €135.00
3148 BPN14770 Potent, selective, allosteric inhibitor of PDE4D €120.00
3169 Crisaborole Potent PDE4 inhibitor; Anti-inflammatory agent €60.00
1127 L 454560 PDE4 inhibitor Inquire
3314 Milrinone PDE3 inhibitor €80.00
1168 Olprinone hydrochloride PDE3 inhibitor €119.00
1482 Parogrelil PDE3 inhibitor €120.00
3179 Pentoxifylline Non-specific inhibitor of cAMP phosphodiesterases €40.00
2352 Roflumilast First specific PDE4 inhibitor licensed for treatment of COPD €90.00
1212 Rolipram PDE4 inhibitor €65.00
1592 SB 207499 PDE4 inhibitor €80.00
1216 Zardaverine PDE3 and PDE4 inhibitor €75.00

15 Item(s)

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