Besides HDACs, multiple sirtuins (NAD+-dependent deacetylase sirtuin, SIRT; EC are known to show deacetylase activity. They are considered class III histone deacetylases that deacetylate histones and transcription factors[1]. In turn, sirtuins can be inhibited by nicotinamide, which binds to a specific receptor site of the enzyme, so it is thought that drugs that interfere with this binding should increase sirtuin activity. Development of new agents that would specifically block the nicotinamide-binding site could provide an avenue for development of newer agents to treat degenerative diseases such as cancer, Alzheimer's, diabetes, atherosclerosis, and gout[2].
SIRT1 is involved in other signaling pathways as well, since it competes with HDAC1 in deacetylation of PTEN, an important phosphatase involved in cell signaling via phosphoinositols and the PI3K/AKT/mTOR signaling pathway. Aiming to keep up with these recent developments in oncology research,Axon Medchem recently added a significant number of HDAC inhibitors to its ever broadening range of products.

[1] Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. S. Hisahara et al. PNAS 2008, 105, 15599-15604.
[2] Sirtuin activators. F.J. Alcaín, J.M. Villalba. Exp. Opin. Ther. Pat. 2009, 19, 403-414.

12 Item(s)

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Axon ID Name Description From price
2249 Tenovin 6 Small water soluble p53 activator and SIRT inhibitor €105.00
2008 Tenovin 1 Activates p53 through inhibition of SIRT 1 and 2 €70.00
1875 SRT 1720 tetrahydrochloride Activator of the sirtuin subtype SIRT1 €95.00
3908 Sirtinol Specific SIRT inhibitor €90.00
2968 SIRT7 inhibitor 97491 Inhibitor of SIRT7 €135.00
2453 SirReal 2 SIRT2 inhibitor with >1000 fold selectivity over SIRT1 and SIRT3 €95.00
1956 Selisistat Potent and selective SIRT1 inhibitor €90.00
2704 Salermide Potent inhibitor of SIRT1 and SIRT2 €95.00
2843 OSS-128167 Selective SIRT6 inhibitor €125.00
2803 Cambinol Inhibitor of SIRT1 and SIRT2 €95.00
2270 AK 7 Potent, brain-permeable and selective inhibitor of SIRT2 €90.00
2269 AK 1 Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 €90.00

12 Item(s)

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