MTH
MTH1 is an oxidized purine nucleoside triphosphatase of the nudix hydrolase family, that sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication, thereby preventing the cytotoxicity and neurotoxicity of oxidized purine nucleotides. In close collaboration with OGG1 (with 8-oxoG DNA glycosylase activity, thus avoiding the accumulation of 8-oxoG in DNA), both MTH1 and OGG1 are expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus. This suggests that MTH1 plays an important role in the prevention of the mutagenicity and cytotoxicity of such oxidized purines as 8-oxoG which are known to accumulate in the cellular genome[1].
[1] Y. Nakabeppu et al.MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.DNA Repair. 2006, 5, 761-772.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2296 | (S)-Crizotinib | MTH1 inhibitor | €85.00 | |
| 2271 | TH 287 hydrochloride | First-in-class MTH1 inhibitor | €95.00 | |
| 2272 | TH 588 hydrochloride | First-in-class MTH1 inhibitor | €90.00 | |
| 3285 | TH1760 | First-in-class, potent, selective and cell-active NUDT15 inhibitor | €130.00 | |