Amidases
Amidases are ubiquitous enzymes and biological functions of these enzymes vary widely. Their proteins structures revealed that aliphatic amidases share the typical a/b hydrolase fold (like nitrilase superfamily) and signature amidases are evolutionary related to aspartic proteinases. They hydrolyze a wide variety of amides (short chain aliphatic amides, mid-chain amides, arylamides, α-aminoamides and α-hydroxyamides) and can be grouped on the basis of their catalytic site and preferred substrate[1].
[1] Amidases: versatile enzymes in nature. M. Sharma, N.N. Sharma, T.C. Bhalla. Rev. Environ. Sci. Biotechnol. 2009, 8, 343-366.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2941 | ARN 272 | Selective inhibitor of FAAH-like anandamide transporter (FLAT) | €90.00 | |
4296 | JNJ 40355003 | Highly potent and selective FAAH inhibitor | Recently added | €120.00 |
1711 | PF 3845 | Selective fatty acid amide hydrolase (FAAH) inhibitor | €115.00 | |
4222 | URB597 | Highly potent, selective and orally available FAAH inhibitor | €70.00 | |
3359 | URB937 | Potent, orally available, and peripherally restricted FAAH inhibitor | €80.00 |