Amidases

Amidases are ubiquitous enzymes and biological functions of these enzymes vary widely. Their proteins structures revealed that aliphatic amidases share the typical a/b hydrolase fold (like nitrilase superfamily) and signature amidases are evolutionary related to aspartic proteinases. They hydrolyze a wide variety of amides (short chain aliphatic amides, mid-chain amides, arylamides, α-aminoamides and α-hydroxyamides) and can be grouped on the basis of their catalytic site  and preferred substrate[1].


[1] Amidases: versatile enzymes in nature. M. Sharma, N.N. Sharma, T.C. Bhalla. Rev. Environ. Sci. Biotechnol. 2009, 8, 343-366.

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