β-Lactamase (Serine)

Sulbactam sodium (Axon 2041) is a rather classical, yet weak inhibitor of beta-lactamase (sub-family of cyclic amid hydrolases; EC 3.5.2.6), used to enhance the antibacterial activity of penicillins and cephalosporins against β-lactamase–producing organisms. β-lactamases may be grouped into four classes, of which A, C, and D are serine hydrolases, and B encompasses metallo-β-lactamases. During several decades, not only have the class A and C enzymes become widely disseminated so as to become the most widespread causes of β-lactam antibiotic-resistant Gram-negative infections in Europeand North America, but many mutant forms have also evolved which are capable of hydrolyzing the expanded-spectrum β-lactam antibiotics[1].


[1] T. Stachyra et al. Mechanistic Studies of the Inactivation of TEM-1 and P99 byNXL104, a Novel Non-β-Lactam β-Lactamase Inhibitor. Antimicrob. Agents Chemother. 2010, 54, 5132-5138.

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Axon ID Name Description From price
2041 Sulbactam sodium An irreversible inhibitor of β-lactamase €70.00

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