NM-3

Based on 20 reference(s) in Google Scholar 80 100 20

Axon N0045

CAS [181427-78-1]

MF C13H12O6
MW 264.23

Purity: >95%
Optical purity: Optically pure
Soluble in DMSO and MeOH

NM-3

Description

Antitumor agent; angiogenesis inhibitor.

Source information: Synthetic analogue of Cytogenin (Axon N0043)

N Matsumoto et al. Synthesis and biological evaluation of cytogenin derivatives. J Antibiot (Tokyo). 2001 Mar;54(3):285-96.

T Tsuchida et al. Convenient total synthesis of NM-3, an antiangiogenesis agent, and its optical resolution. J Antibiot (Tokyo). 2003 Jan;56(1):38-41.

T Nakashima et al. Inhibition of angiogenesis by a new isocoumarin, NM-3. J Antibiot (Tokyo). 1999 Apr;52(4):426-8.

RM Salloum et al. NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 2000 Dec 15;60(24):6958-63.

CL Reimer et al. Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis. Cancer Res. 2002 Feb 1;62(3):789-95.

N Agata et al. The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel. Cancer Chemother Pharmacol. 2005 Dec;56(6):610-4.

Natural product

Antitumor, angiogenesis inhibitor

Chemical name

2-(8-Hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propanoic acid

Parent CAS No.

[181427-78-1]

Related Products

Axon ID	Name	Description	From price
N0043	Cytogenin	Angiogenesis inhibitor, immunomodulator		Inquire

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