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Migrastatin

Based on 57 reference(s) in Google Scholar 8 10 57

Axon N0033

CAS [314245-65-3]

MF C27H39NO7
MW 489.60

Purity: >95%
Optical purity: Optically pure
Soluble in DMSO and MeOH

Migrastatin

Description

Tumor cell migration inhibitor, antitumor. Source information: Streptomyces sp. MK929-43F1

K Nakae et al. Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000 Oct;53(10):1130-6.

Y Takemoto et al. Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells. J Antibiot (Tokyo). 2001 Dec;54(12):1104-7.

Y Takemoto et al. Suppression of multidrug resistance by migrastatin. J Antibiot (Tokyo). 2006 Jul;59(7):435-8.

K Nakae et al. Migrastatin acts as a muscarinic acetylcholine receptor antagonist. J Antibiot (Tokyo). 2006 Nov;59(11):685-92.

Natural product

Tumor cell migration inhibitor, antitumor

Chemical name

4-((S)-5-((2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl)-4-oxohexyl)piperidine-2,6-dione

Parent CAS No.

[314245-65-3]

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