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Natural product
Inostamycin A sodium salt

Inostamycin A sodium salt

Based on 37 reference(s) in Google Scholar 8 10 37

Axon N0029

CAS [1884611-95-3]

MF C38H67NaO11
MW 722.92

Purity: >90%
Optical purity: Optically pure
Soluble in DMSO

Inostamycin A sodium salt

Description

Antitumor. Source information: Streptomyces sp. MH816-AF15

M Imoto et al. Isolation and structure determination of inostamycin, a novel inhibitor of phosphatidylinositol turnover. J. Nat. Prod. 1990, 53(4), 825-829).

M Imoto et al. Inhibition of CDP-DG: inositol transferase by inostamycin. J Biochem. 1992 Aug;112(2):299-302.

M Imoto et al. Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells. Jpn J Cancer Res. 1998 Mar;89(3):315-22.

Y Baba et al. Inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, suppresses invasion ability by reducing productions of matrix metalloproteinase-2 and -9 and cell motility in HSC-4 tongue carcinoma cell line. Clin Exp Metastasis. 2000;18(3):273-9.

Y Baba et al. Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines. Cell Biol Int. 2001;25(7):613-20.

Huczyński A. Polyether ionophores-promising bioactive molecules for cancer therapy. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7002-10.

Natural product

Active as antifumor

Chemical name

sodium (R)-2-((2R,3S,4R,5S,6R)-5-ethyl-6-((2S,3S,4S,6R)-6-((2S,2'R,3'R,4S,5S,5'R)-5'-ethyl-2'-hydroxy-5'-((S)-1-hydroxybutyl)-2,3',4-trimethyloctahydro-2,2'-bifuran-5-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-2,4-dihydroxy-3-methyltetrahydro-2H-pyran-2-yl)b

Parent CAS No.

[129905-10-8]

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