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Heparastatin hydrochloride

Heparastatin hydrochloride - SF4 hydrochloride

Based on 5 reference(s) in Google Scholar 8 10 5

Axon N0027

CAS [153758-26-0]

MF C8H11F3N2O5.HCl
MW 308.64

Purity: >95%
Optical purity: Optically pure
Soluble in water, DMSO and MeOH

Heparastatin hydrochloride

Description

Heparanase inhibitor

Y Nishimura et al.. Effect on spontaneous metastasis of mouse Lewis lung carcinoma by a trifluoroacetamide analogue of siastatin B. J Antibiot (Tokyo). 1994 Jul;47(7):840-2.

Y Nishimura et al. Flexible synthesis and biological activity of uronic acid-type gem-diamine 1-N-iminosugars: a new family of glycosidase inhibitors. J Org Chem. 2000 Jan 14;65(1):2-11.

M Sue et al. An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches. Int Immunopharmacol. 2016 Jun;35:15-21.

Heparanase inhibitor

Chemical name

4,5-dihydroxy-6-(2,2,2-trifluoroacetamido)piperidine-3-carboxylic acid hydrochloride

Parent CAS No.

[153758-25-9]

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